Biomedical Research

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The influence of Astragli on the interleukin, IFN-γ and Th1Th2 balance in rats with airway inflammation

Objective: To explore the influence of Astragli on the interleukin, IFN-γ and Th1Th2 balance in rats with airway inflammation.

Methods: The blank group, model group, Astragli group, Angelica group and compatibility group were relatively set and the method of drug gavage treatment of rats with allergic inflammation was used. Inflammatory model of rats was induced by ovalbumin spray method and interleukin, IFN-γ and Th1Th2 balance were observed in serum, lung tissue and nasal mucosa of rats.

Results: IFN-γ level decreased in the lung tissue, nasal mucosa and serum of rats in the model group, while interleukin increased, and related indicators of lung tissue and nasal mucosa had a certain relevance; single Astragli had the function of reducing IFN-γ level of nasal mucosa and serum as well as reducing interleukin in serum and lung tissue; single Angelica had the function of decreasing interleukin in the nasal mucosa, serum and lung tissue. The compatibility of Astragli and Angelica could elevate IFN-γ level in the serum and lung tissue as well as reduce interleukin in the nasal mucosa, serum and lung tissues.

Conclusion: The compatibility of Astragli and Angelica plays a regulatory role in balancing the two cytokines Th1 and Th2 in the body, functioning in suppressing allergic airway inflammation.

Author(s): Jianhong Liu