Biomedical Research

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The effects of ZJXG decoction on the serum CT levels and the expressions of CTR and Cbfα1 in callus of femur fracture rats.

Zhuang Jin Xu Gu decoction is a well-known traditional-chinese medicine prescriptionon. The present study investigated the effects of the serum level of calcitonin, the expressions of calcitonin receptor and core binding factor α1 in callus of femur fracture rats. The rats were randomly divided into shamoperated group, model group, control group and treatment group. The rats in the treatment group were gavaged with Zhuang Jin Xu Gu decoction for 28 days whereas those in the other three groups were given an equal amount of normal saline. The serum level of calcitonin was detected by enzyme linked immunobsorbent assay. The fracture healing process was analyzed by X-ray and hematoxtlin-eosin staining. The expressions of calcitonin receptor and core binding factor α1 in callus were evaluated by immunohistochemical staining. Changes in the levels of calcitonin in the serum, calcitonin receptor and core binding factor α1 in callus of the rats were measured. The results of the study showed that Zhuang Jin Xu Gu decoction might promote fracture healing by inhibiting the degradation of calcitonin to remain at a high level and promoting the expression of calcitonin receptor and core binding factor α1 in callus at various stages after fracture.

Author(s): Zhen Zhou, Chi Ning, Guangwen Yang, Lixin Jin, Yunliang Guo