Research Article - Biomedical Research (2017) Volume 28, Issue 19
The effects of interventional therapy with endovascular stents for ischemic cerebrovascular disease
Objective: To explore the effects of interventional therapy using endovascular stents on the perioperative and long-term postoperative period for patients with Ischemic Cerebrovascular Disease (ICVD) induced by vertebral-basilar ischemia.
Methods: From January 2014 to August 2015, seventy-one patients with ICVD induced by vertebralbasilar ischemia were treated in our hospital and retrospectively analysed. According to the method of treatment, all patients were divided into the stent group (treated with endovascular stents, n=33) and drug group (treated with drug therapy, n=38). Baseline parameters, recurrence rate during the followup period, comprehensive scores of vessel lesions before and after treatment, and neurologic deficit scores at 1, 3, 6, and 12 months after treatment were compared between two groups to evaluate the clinical value of interventional therapy.
Results: The follow-up data showed that the recurrence rate of patients in the stent group (3/33, 9.09%) was significantly lower than that in the drug group (9/38, 23.68%) (p<0.05). There was no significant difference in the comprehensive scores of vessel lesions or neurological deficit scores before treatment between both groups (p>0.05). At 1 w and 12 months after treatment, the comprehensive scores of vessel lesions in the stent group were significantly lower than in the drug group (p<0.05). At 1, 3, 6, and 12 months after treatment, the neurological deficit scores in the stent group were significantly lower than in the drug group (p<0.05).
Conclusions: Both interventional therapy using endovascular stents and drug therapy are effective for the treatment of ICVD caused by vertebral-basilar ischemia. The perioperative and long-term follow-up effects of interventional stent treatment were more obvious than with drug therapy alone. Stenting intervention therapy is better for treatment of ICVD induced by vertebral-basilar ischemia.Author(s): Dawei Zhu, Jingjian Wang, Jingfeng Liu