Biomedical Research

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The comparison of the safety and effectiveness of multiple insulin injections and insulin pump therapy in treating gestational diabetes

Objectives: To observe and compare the treatment effect of multiple insulin injections and insulin pump therapy on pregnant women with gestational diabetes.

Methods: From January, 2015 to May, 2017, 90 pregnant women with gestational diabetes enrolled in Linyi Chinese Medicine Hospital were collected and randomly divided into research group and reference group. In the research group, 45 patients were treated with insulin pump therapy. All 45 patients in the reference group were treated with multiple insulin injections therapy. General treatment effect of these two groups was then observed and compared.

Results: After treatment, in research group, patients’ fasting blood-glucose level was 5.2 ± 0.6 mmol/L, 2 h post-meal blood sugar level was 7.3 ± 1.2 mmol/L and the blood-glucose standard time was 2.5 ± 0.8 d; However, in the reference group, the fasting blood-glucose level was 6.8 ± 0.6 mmol/L, 2 h post-meal blood sugar level was 8.8 ± 1.2 mmol/L and the blood-glucose standard time was 6.9 ± 1.4 d, P<0.05. When comparing the changes of peripheral blood sugar between the 2 groups after treatment, in research group, the peripheral blood sugar level was 4.8 ± 0.7 mmol/L before breakfast, 5.3 ± 1.2 mmol/L after breakfast, 5.8 ± 1.2 mmol/L before lunch, 5.4 ± 1.2 mmol/L after lunch, 5.2 ± 1.0 mmol/L before dinner, 6.3 ± 1.1 mmol/L after dinner, 6.7 ± 1.4 mmol/L before sleep, while in reference group, the peripheral blood sugar level was 3.6 ± 0.8 mmol/L before breakfast, 6.5 ± 2.3 mmol/L after breakfast, 6.6 ± 1.5 mmol/L before lunch, 7.3 ± 1.5 mmol/L after lunch, 5.8 ± 1.2 mmol/L before dinner, 8.6 ± 1.7 mmol/L after dinner, 7.3 ± 1.3 mmol/L before sleep, P<0.05. Hypoglycemia occurred more frequently in reference group than in the research group after calculation and observation.

Conclusion: Compared with multiple insulin injections therapy, the project of treating gestational diabetes patients with insulin pump therapy has more precise effect. Additionally, it has great safety and reliability, along with huge application value.

Author(s): Jie Xie, Lan Dai, Xiaolei Tang