Objective: This research was to study the anti-inflammatory and analgesic effects of Climbing Groundsel Herb ethanol extracts. And observe its mechanism of action preliminarily.
Methods: HAC writhing reaction and hot plate test were used to observe the analgesic effect of senecio. The mouse ear swelling induced by xylene, the rat granulation tissue hyperplasia induced by cotton ball and rat egg white paw edema study of anti-inflammatory effect of senecio. Through the determination of formaldehyde in mice analgesia experiment and rat foot claws inflammatory exudate of PGE2 content to study the anti-inflammatory and analgesic mechanisms.
Results: Groundsel ethanol extract can significantly decrease The Times of the mice body torsion and significantly increase the pain threshold of mice, the mouse ear swelling induced by xylene, induced rat granulation tissue hyperplasia induced by cotton ball and egg qing to rats foot swelling has obvious inhibitory effect; and to reduce the formaldehyde in mice analgesia experiment II pain reaction, can reduce rats foot claws inflammatory exudate content of PGE2.
Conclusion: The alcohol extracts of Senecio scandens Buch-Ham. have obvious anti-inflammatory analgesic effect, and has a certain peripheral analgesic activity, its anti-inflammatory effects may be related to its inhibition of PGE2 synthesis or release from inflammatory tissue.