Research Article - Biomedical Research (2017) Volume 28, Issue 5

Synthesis and in vitro evaluation of anti-breast cancer activity of a novel Dy (II) coordination polymer

Discuss here is a kind of novel Dy-based Metal Organic Frameworks (MOF) material, ((Dy(H₂O)(PBA) (SO₄))(DMA)2(H₂NC₂H₆))n(1 H₂PBA=4-Hydroxybenzoic acid; the DMA=N,N-Dimethylacetamide), from the solvothermal synthesis conditions and using sulfuric acid as the PH controller and template. The X-ray studies shown that 1 is a 3D two-fold interpenetrated MOF built up from 1D-Dy (III) ribbon chains and PBA^2- ligands. 1 title compound anti-breast cancer activity and organic ligand (H2PBA) survey of four kinds of human breast tumor cell line (BT474, ZR-75-30, MDA-MB-453 and Hs-578T) determined by MTT test. Found that compared with organic ligands, compound 1 exerted rather potent activity against all of these cell lines.

Author(s): Xiaowen Ding, Wenju Mo, Shuai Zhao, Hongjian Yang, Dehong Zou, Xiping Zhang

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