Biomedical Research

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Study on the correlation between ultrasonic imaging features in breast cancer and the expression of ER, PR, HER-2 and nm23

Objective: To investigate the ultrasonographic features of breast cancer, and analyse its correlation with ER, PR, HER-2 and nm23.

Methods: Female patients with breast cancer from January 2015 to December 2016 were selected and retrospectively analysed ultrasound imaging performance in accordance with the inclusion criteria. And immunohistochemical method was used to detect the expression of ER, PR, HER-2 and nm23 in pathological specimens to analyse its correlation with ultrasonic imaging features.

Results: The positive rate of ER, PR in patients with spiculation in the lumps’ edge was significantly higher than that of patients with no spiculation in the lumps’ edge (P<0.05). The positive rate of PR in lumps<2 cm was significantly higher than that of the large lumps (P<0.05); the positive rate of ER, nm23 in patients whose blood flow was grades 0-I was significantly higher than that of grades II-III (P<0.05). The positive rate of HER-2 in the patients with microcalcification in the lumps was significantly higher than that without calcification (P<0.05); the positive rate of nm23 in patients with aspect ratio>1 in the lumps was greater than that of patients with aspect ratio ≤ 1 (P<0.05). Whether the lesion of breast cancer had rear echo increased or not had no significant relationship with the positive rate of ER, PR, HER-2 and nm23.

Conclusion: There is correlation between ultrasonic performance in breast cancer and the expression of ER, PR, HER-2 and nm23, and through the features of ultrasound, the expression of ER, PR, HER-2 and nm23 in lesion of tumor can be partly estimated.

Author(s): Shu-Ping Zhang, Wei Wang, Yang Gu, Lan Jin, Fang Zhou