Biomedical Research

- Biomedical Research (2010) Volume 21, Issue 4

Study of lipid profile and oxidative stress in chronic renal failure

Chronic renal failure is a debilitating disease which leads to many complications, most com-mon being cardiovascular. Hence this study was undertaken to know the risk of cardiovas-cular morbidity in CRF patients. The levels of serum TG, TC, LDL-C, VLDL-C, TC/HDL-C and LDL-C/HDL-C ratio were significantly increased and HDL-C was significantly de-creased in cases when compared to controls. Serum TG, TC, VLDL-C and HDL-C are sig-nificantly increased in conservatively managed patients than hemodialysis patients. Serum MDA was significantly increased and SOD was significantly decreased in cases when com-pared to controls. These changes were more pronounced in hemodialysis patients when compared to conservatively managed patients. We also did the correlation between lipid and oxidative stress parameters, in which serum MDA was positively correlated with all the lipid parameters except HDL-C and serum SOD was negatively correlated with all lipid parame-ters except for HDL-C. This study suggests that increased lipoproteins along with increased oxidative stress leads to accelerated atherosclerosis in CRF patients.

Author(s): Sumathi M.E, Manjunath M Tembad, Jayaprakash murthy D.S, Preethi B.P

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