Biomedical Research

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Study of ALA and small dosage of HPD photodynamic therapy (HPD-PDT) in treatment of skin cancer

Objective: To investigate clinical effect of ALA and small dosage of HPD-PDT in treatment of patients with skin cancer.

Methods: From June 2014 to April 2017, 62 cases of malignant skin tumor patients treated in our hospital were selected as the objects and randomly divided into study group (31 cases) and control group (31 cases), respectively treated by ALA and small dosage of HPD-PDT and conventional HPD-PDT. The clinical effective rate and recurrence incidence in the two groups were compared to explore therapeutic effect of ALA and small dosage of HPD-PDT on skin cancers of different types.

Results: The effective rate of the study group (100%) was significantly higher than that of the control group (87.09%) while the recurrence rate of the study group (3.23%) was significantly lower than that of the control group (19.35%) of statistical significance, P<0.05. Besides, the study group has more significant effects in treatment of skin cancers like adnexal tumor, basal cell carcinoma, malignant melanoma and squamous cell carcinoma.

Conclusion: The clinical effect of ALA and small dosage of HPD-PDT has significant curative effects in the treatment of various skin tumors.

Author(s): Wei Lu, Wei Feng, Yi Tang, Xiaohua Tao, Lei Pan