Introduction: It is estimated that between 5-15% of normal individuals harbor group A ß-hemolytic Streptococcus (GABHS) usually in the respiratory tract, without signs of disease. GABHS disorders and its side effects are the major concern especially in pediatric populations. The prevalence of GABHS and delayed immunologic side effects and also antibiotic susceptibility among young population in different parts of Iran is so important. Materials and methods: Twenty five 25 indexed studies (laboratory or medical reports) about GAS in Iranian population (English or Persian with English abstract) between 2000- 2015 reviewed. Conclusion: The carrier state for GABHS in Iranian children is much lower (3-6%) than its rate in children living in developed countries but recently a high rate of Group G streptococci were reported in Iran. Frequent antibiotic treatment in Iran; exposure at different ages and different seasonality could be the reasons for this wide differences. Rapid immunological GABHS antigen test in comparison with conventional throat cultures, showed higher advantage for diagnosis especially in the cases with previous antibiotic usage.