Biomedical Research

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Role of stromal vascular fraction in severe burn wound healing process

Objective: To determine role of Stromal Vascular Fraction (SVF) in wound healing process of hot water induced burns.

Materials and methods: Wound healing is characterized as the reclamation of the congruity of living tissue and is an incorporated reaction of a few cell types to damage. SVF was obtained from inguinal fat of rats. Artificial burns were induced in rats with help of hot water. VEGF, PCNA analysis performed in different groups with histological evaluation of deep burns and fibrosis.

Results: On day 10, aggravation intensity was watched to be extraordinarily expanded in the control set, while it was diminished in the treatment group and the contrast between the groups was measurably critical. The Vascular endothelial growth factor (VEGF) values were statistically significant between the therapy and control groups at 3 and 10 days. Statistically significant differences were observed among day 3 and other days in both the groups.

Conclusion: The wound healing benefit is associated with a more efficient vascular network. This topical therapy provides a potential novel therapy for the treatment of various wound based atrophies.

Author(s): Hongwei Yan, Ximei Xing, Hong Li, Haoyun Yan, Xia Li, Jianping Zhu