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Research on pathogenic bacteria and antibiotic resistance of Enterobacteriaceae in hospitalized elderly patients

Objective: To observe the pathogens types of Enterobacteriaceae infection in hospitalized elderly patients, and analyse its drug resistance of germ and provide laboratory evidence for clinical prevention and treatment in the future.

Methods: The clinical data of hospitalized elderly patients (≥ 60 y) from July, 2009 to June, 2017 were retrospectively analysed, identification of the strain was conducted after using conventional methods for separation of Enterobacteriaceae, and the disk diffusion method (K-B) was adopted for detecting the drug resistance of bacteria to various antimicrobial agents.

Results: In this study, 3541 cases were confirmed with the occurrence of hospital infection from Enterobacteriaceae, and 2338 strains of Enterobacteriaceae were isolated, of which 771 strains of Escherichia coli (32.98%), 682 strains of Klebsiella (29.17%) with the highest relevance ratio. The drug resistance rates of Escherichia coli to sulfamethoxazole were the highest (98.57%) and that of Klebsiella pneumoniae reached 82.99%. They were followed by ciprofloxacin and levofloxacin. The drug resistance rates of Escherichia coli to ciprofloxacin and levofloxacin were higher than Klebsiella pneumoniae (p<0.05). In every sample, the drug resistance rates of sulfamethoxazole, ciprofloxacin and levofloxacin were relatively high. The drug resistance of cefotaxime and piperacillin in the drainage liquid samples were higher than other, but that of sulfamethoxazole was lower than the urine samples (p<0.05). The drug resistance of levofloxacin, imipenem, meropenem and sulfamethoxazole in the sputum sample were lower than urine samples (p<0.05).

Conclusion: The Enterobacteriaceae bacteria produce the drug resistance to many antibiotics, which affects the treatment effect of hospitalized elderly patients. The antibacterial agents should be properly used and the distribution condition of pathogenic bacteria and drug resistance of patients should be closely monitored.

Author(s): Feng Zheng, Xiang-zhu Meng