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Relationship of prophetic factors associated with antioxidative, immune system and micronutrients status in breast cancer patients underwent surgical procedures.

Background: Surgical intervention induces additional stress also affecting the dynamics of antioxidative, micronutrients and immune systems. Surgical treatments can deepen already existing injury in the immune system of cancer patients. Objective: The aims of the present study were to appraise the prognostic factors associated with anti-oxidative, micronutrients status and immune systems in patients with breast cancer underwent surgical procedures. Methodology: Current study estimated the levels of (SOD, CAT, GPx, GRx) and non-enzymatic antioxidants (Vit-A, Vit-C, Vit-E), micronutrients (Zn, Fe, Mn, Se, Cu) along with oxidative biomarkers (MDA, IL-10) in patient?s serum samples before and after surgical intervention. The results were compared with healthy individuals via different lab tests and ELIZA kits. Results: The enzymatic antioxidants such as SOD, CAT, GSH and GPx were considerably low in females with breast cancer as compared to healthy females. Which further decreases after surgery Results before and after surgical intervention of breast cancer patients displayed that non-enzymatic antioxidant Vit-A (78.91 ± 6.5 ?g/ml vs. 59.32 ± 8.3 ?g/ml), Vit-C (1.06 ± 0.38 ?g/ ml vs. 0.99 ± 0.11 ?g/ml), and Vit-E (2.47 ± 0.79 ?g/ml vs. 2.25 ± 0.57 ?g/ml) were decreased. Similarly increasing trends within MDA (8.04 ± 1.37 nmol/ml vs. 2.57 ± 0.81nmol/ml), IL-10 (312 ± 0.71pg/ml vs. 263 ± 1.97 pg/ml) were depicted in patients and were further increased after surgical interventions. The scrutiny of micronutrients (Fe, Zn, Mn, Cu and Se) in controls and breast cancer females shows significant decline. Conclusion: The current study portrays that fluctuation from normal levels of micronutrients and antioxidants significantly contributes in the progression of breast cancer. Already existing damage in the immune system of breast cancer patients get more intensified because of surgical intervention which is responsible for increased cytokines and oxidative stress that reduces s because of inflammation that enhance interleukins and oxidative stress which is responsible for decrease in antioxidant capability.

Author(s): Arif Malik*, Maira Mahmood Bukhari, Mahwish Arooj, Rabia Rasool, Sulayman Waquar, Mahmood Husain Qazi