Research Article - Biomedical Research (2018) Volume 29, Issue 5

Retracted: Relationship between SLC22A1 and SLC22A4 gene polymorphisms and risks of type 2 diabetes in Chinese Han population

Objective: This study was conducted to investigate the relationship between SLC22A1 and SLC22A4 gene polymorphisms and genetic susceptibility to type 2 diabetes in Chinese Han population.

Methods: The research group comprised 110 patients with type 2 diabetes in Chinese Han population, while and the control group consisted of 110 healthy volunteers. The polymorphisms of SLC22A1 gene rs628031 and rs2282143 loci and SLC22A4 gene rs2073838 and rs272893 loci were detected in the subjects in the two groups. Genotype distributions and allele frequencies of the two genes were compared between the research and control groups.

Results: Statistically significant differences were identified in the genotype distributions of SLC22A1 gene rs628031 and rs2282143 loci between the research and control groups (P<0.05). The A allele frequency of SLC22A1 gene rs628031 locus and the T allele frequency of rs2282143 locus were higher in the research group than in the control group; these differences were statistically significant (P<0.05). The genotype distributions and allele frequencies of SLC22A4 gene rs2073838 locus exhibited no significant difference between the research and control groups (P>0.05). However, the genotype distributions of rs272893 locus showed a significant difference between the research and control groups (P<0.05).

Conclusion: The polymorphisms of SLC22A1 gene rs628031 and rs2282143 loci and SLC22A4 gene rs272893 locus of patients with type 2 diabetes indicated a significant difference between the research and control groups, thereby suggesting that these genetic locus mutations increase the risk in patients with type 2 diabetes in Chinese Han population.

Author(s): Guanghui Long, Guangtao Zhang, Fangting Zhang, Dongshuo Ye, Dengke Yang, Yinke Yang

Abstract PDF