This study aimed to investigate the prognostic values of high-sensitivity C-Reactive Protein (hs-CRP) for patients receiving Percutaneous Coronary Intervention (PCI). 89 patients receiving PCI from September 2010 to December 2012 were selected as the study subjects. Before PCI surgery, the serum indexes including hs-CRP, total cholesterol, high-density lipoprotein cholesterol, urea and apolipoprotein A were measured. After surgery, the patients were followed up for 3 years. The readmission and death due to cardiovascular diseases were used as the end point events. The corrections of serum indexes with the end point events were analysed. Results showed that, the level of hs-CRP was significantly correlated with cardiovascular readmission and cardiovascular death, respectively (P<0.05). Logistic regression analysis showed that, hs-CRP was a risk factor for cardiovascular readmission and cardiovascular death (OR was 1.874 and 6.279, respectively; 95% CI was 1.052-2.460 and 4.310-7.521, respectively). hs-CRP is a risk factor for cardiovascular readmission and cardiovascular death after PCI, and it can be used for evaluate the prognosis of patients with PCI.