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Preventive effect of probiotics to the postoperative infection for surgical patients with obstructive jaundice

Objectives: To investigate the perioperative application of probiotics on postoperative infectious complications.

Patients and Methods: A total of 58 cases of upper abdominal surgery patients with obstructive jaundice were collected and divided into two groups, the control group B routinely get preoperative preparation before surgery 3 days, and the probiotics group A get oral intestinal microbial agents 2.0 g, 3 times per day in the preoperative 5 days, the inflammation indicators and postoperative infection complications were observed after treatment.

Results: After treatment for 1 week, the inflammation indicators include CRP, IL-6, and endotoxin in Probiotics Group were significantly lower than control group B after operation, the level of CRP, IL-6, endotoxin were 14.90 ± 3.99, 151.14 ± 26.62 and 0.034 ± 0.007 in group A respectively, while in group B which is 17.00 ± 3.94, 172.07 ± 41.29, 0.039 ± 0.011 respectively (P<0.05). The overall incidence of complications was 58.6% in control group and 27.6% in observation group (P<0.05), respectively.

Conclusion: Perioperative administration of probiotics can reduce postoperative inflammatory reaction, inhibit infection and reduce postoperative complications associated with infections.

Author(s): Wei-Feng Yao, Jun-Wei Liu, Dongsheng Huang