Biomedical Research

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Preventive effect of Aster tataricus on oxidative stress and biomarker of renal function in rat fed with high fat diet and sucrose diet

Present investigation evaluates the antioxidant and renal protective effect of Aster tataricus (AT) obesity induced rats. Obesity was induced by High Fat Diet (HFD) and High Sucrose Diet (HSD) for the duration of 8 weeks. All the rats induced to obesity were given AT (100 and 200 mg/kg, orally (p.o.)) for next 4 weeks along with HFD and HSD. The obesity protocol resulted in a significant rise in intake of feed, body weight, body mass index and weights of adipose tissue. AT significantly decreased intake of feed, reduced body weight, adipose tissues and body mass index in a dose dependent manner. The two diets affected lipid profile and renal function, treatment of AT improved overall lipid profile in dose dependent manner and also marked a protective role on renal function by decreasing levels of creatinine and urea. AT corrected increased glucose levels and decreased Glucose 6-phosphate dehydrogenase (G6PD) activities in HFD and HSD fed rats. The treatment improved the antioxidant status by decreasing serum and renal MDA levels followed by increasing catalase activity. Decrease in Nitric Oxide (NO) was observed in HFD and HSD rats, treatment resulted in increased NO levels with increasing dose of AT. Thus present study concludes the protective effect of Aster tataricus on renal function and markers of oxidative stress in HFD and HSD fed obese rats.

Author(s): Xin Yao, Xue Dong, Hong-Shi Zhang, Yang Wang, Lan-Yuzhu, Xing-Shan Liu