Biomedical Research

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Post-operative change in colloid osmotic pressure and its clinical significance after heart surgery in adults

Objectives: This study aimed to investigate the post-operative change in Colloid Osmotic Pressure (COP) and its significance in clinical prognosis in adults receiving heart surgery.

Methods: A total of 21 adults receiving heart surgery were recruited and divided into CPB group (valve replacement under cardiopulmonary bypass) and OP group (minimally invasive coronary artery bypass surgery). The COP was recorded at 5 min after anesthesia (T0), 5 min after initiation of CPB (T1), 5 min after the end of CPB (T2), post-operative return to ICU (T3), 2 h (T4), 4 h (T5), 8 h (T6), 24 h (T7) and 3 days after surgery, and the duration of mechanical ventilation and ICU stay were also recorded for comparisons between them.

Results: The baseline characteristics were comparable between two groups before surgery. The perioperative COP reduced to different extents in both groups, but there was no significant difference between them (P>0.05). The change in intra-operative COP was the most obvious (P<0.05). The incidence of complications, post-operative ICU stay and duration of mechanical ventilation were comparable between two groups (P>0.05).

Conclusions: CPB surgery may reduce COP, but it restores rapidly after management, and the change in COP has no influence on the clinical prognosis.

Author(s): Xiaoyun Wu, Yuanmin Li, Xianglan Jin, Yinmei Liu, Wangfu Zang