Effect of Tinospora cordifolia (Willd.) (TC) stem extracts (both aqueous and alcoholic) in different dosages (200 and 400 mg/ kg b.w) on kidney weight, morphology, serum creatinine, renal gluconeogenic enzymes Glucose-6-phosphatase and Fructose 1, 6-bisphosphatase activity in streptozotocin induced diabetic albino rats was investigated in this study. The drug was administered orally for 10 and 30 days in different groups. Efficacy of TC in modulating all these altered parameters caused by diabetes was compared with the Lante Zinc Insulin (6 Units / kg b.w. daily. i.p.) treated diabetic rats. Drug treated diabetic animals showed a significant effect (p< 0.05) of TC on all these parameters except renal morphology, compared to untreated animals. Moreover, the drug administration in control animals did not induce significant change in any one of these parameters, showing that TC administration is safe in normal animals.