Renal cell carcinoma is the most common malignant tumor of the kidney. Thirty percent of the patients have distant organ metastasis at diagnosis. The lungs, bones, liver, lymph nodes and mediastinal metastasis are the most common regions. Metastasis is very rare in the head and neck region. In our study, the diagnosis and the treatment of two patients after nephrectomy due to renal cell carcinoma and other two patients with distant organ metastases at diagnosis, totally 4 patients were discussed with literature data.