- Biomedical Research (2015) Volume 26, Issue 4
Long-term assessment of bone formation in response to Gen Os and Gel 40 xenografts
in an experimental rat model
The study?s aim was to assess long-term bone healing associated with two different xenografts in
an experimental model of parietal bone defects in rats. We surgically created two symmetrical,
full-thickness, parietal bone defects 5 mm in diameter in each of 12 rats, which were then divided
randomly into three groups (eight defects per group): group 1, defects filled were with
Gen Os; group 2, defects were filled with Gel 40; and group 3 (control) defects were left empty.
There was substantial bone formation in group 1, but no to minimal bone formation was seen in
the other groups. Significant differences were observed between groups 1 and 2 and groups 1
and 3 (p < 0.05 for both). Gen Os and Gel 40 were both osteoconductive and biocompatible.
Based on the long-term outcomes in our study, Gen-Os xenograft is more conducive to bone regeneration,
but further studies are required Author(s): Hakan Develio?lu, Serpil ├ťnver Sarayd?n, Zeliha Akkus, Zeynep Deniz Sahin, Olcay Bakar
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