Previous studies investigated the association between the IL-6-572C/G polymorphism and chronic periodontitis risk. However, the results were inconclusive. Therefore, we performed this study to assess the association between IL-6-572C/G polymorphism and chronic periodontitis risk. We included 231 patients with chronic periodontitis and 259 healthy controls. IL-6 sequence amplification was done using polymerase chain reaction (PCR). Subjects with CG genotype showed an increased risk of chronic periodontitis (OR=1.52, 95%CI 1.06-2.21). In addition, individuals with GG genotype had a higher risk of chronic periodontitis (OR=4.53, 95%CI 1.43-14.21). Carriage of the G-allele was significantly associated with chronic periodontitis risk (OR=1.62, 95%CI 1.19-2.22). In conclusion, this study found a significant association between IL-6 -572C/G polymorphism and chronic periodontitis risk.