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Interleukin-6 rs1800795 polymorphism is not a risk factor of hypertension

The role of IL-6 rs1800795 polymorphism in the development of hypertension has been inclusive. Therefore, the purpose of our study was to determine whether there is an association between IL-6 rs1800795 polymorphism and hypertension risk. PubMed, Embase and China National Knowledge Infrastructure (CNKI) were searched till Jun 2017. A total of 7 case-control studies with 1231 cases and 1122 controls were included. We did not found a significant association between IL-6 rs1800795 polymorphism and the susceptibility to hypertension (OR=0.94; 95% CI, 0.71-1.24; P=0.67). In the subgroup analysis of race, both Asian (OR=1.52; 95% CI, 0.15-15.48; P=0.73) and Caucasian (OR=1.01; 95% CI, 0.84-1.21; P=0.92) with IL-6 rs1800795 polymorphism did not show significant associations. In conclusion, this meta-analysis suggested that IL-6 rs1800795 polymorphism was not associated with the risk of hypertension.

Author(s): Sheng Yue, Jian Jia, Ning Zhang, Yi-Yang Zhan, Hai-Xia Ding