Biomedical Research

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Influence of antimicrobial agents in postoperative infection for patients with gastric cancer

Objective: To investigate the effect of antibacterial agents on postoperative infection in the patients treated with gastric cancer surgery.

Methods: From March 2015 to March 2016, a total number of 60 patients suffering gastric cancer enrolled in our hospital were selected and divided into treatment group and control group evenly according to the treatment of different. The control group was treated with cephalosporins (cefoxitin) while the treatment group received the treatment of cephalosporin combined with anti-anaerobic fungal drugs (metronidazole). The treatment effect, recurrence rate, postoperative infection and the distribution of pathogenic bacteria after operation were compared between the two groups.

Results: Compared with the control group, the clinical effect of the treatment group was better, the recurrence of postoperative infection was lower and the distribution of pathogenic bacteria after operation was less of statistical significance with significant difference between two groups (P<0.05).

Conclusion: Antimicrobial drugs can effectively reduce the postoperative infection of patients with gastric cancer and improve the treatment outcomes. But the curative effect of combination therapy is better than that of single drug treatment and it has great significance for preventing postoperative infection in patients with gastric cancer.

Author(s): Chunying He, Chunling Li, Yao Zhang, Binbin Song, Liping Wang