Research Article - Biomedical Research (2017) Volume 28, Issue 12

Impacts of different hemofiltration methods on the prognosis of patients with sepsis

The aim of this study was to explore the therapeutic effects of Continuous High-Volume Hemofiltration (CHVHF) in treating sepsis combined with Multiple Organ Dysfunction Syndrome (MODS). A total of 100 patients with sepsis induced by various causes in combination with MODS (S-MODS) and who were treated in the Department of Critical Care Medicine of our hospital from March 2013 to December 2015 were selected and randomly divided into group A (n=53, for CHVHF) or group B (n=47, for common volume hemofiltration, CVHF). The post-treatment changes of observation indexes were then compared and analysed. Patients in group A exhibited an improvement in body temperature and heart rate (P<0.01), while their Color Index (CI), Mean Artery Pressure (MAP), Systemic Vascular Resistance Index (SVRI), and Stroke Volume Index (SVI) all tended to be stable (P<0.01). Meanwhile, their MODS scores and APACHEII scores decreased significantly (P<0.01), and their Procalcitonin (PCT) and Arterial Blood Lactate level (ABL) improved after treatment. Therefore, CHVHF can stabilize the vital signs and hemodynamics of S-MODS patients as well as improve their tissue perfusion and restore organ functions.

Author(s): Jilu Ye, Xuehua Pu, Xiaofeng Chen

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