The aim of this study is to investigate the hemodynamic characteristics of brain death patients via Pulse- Induced Contour Cardiac Output (PiCCO). 20 brain-death patients were included in the test group, and 20 with GCS ≥ 8 were included in the control group. The hemodynamic characteristics Pre-load (ITBVI/ EVLWI), Cardiac Pump Function: (CI/SI/GEF/CFI/dPmax), Post-load: (SVRI) were collected by PiCCO at 0, 6, 12, 24 and 48 h were compared between 2 groups, dopamine and pituitary hormone can be used in some unstable patients in the test group. The preload ITBVI in test group at 0 h was lower than the control group (P<0.05), but no difference after volume management at 6 h. After volume management, the result of post-load SVRI in the test group decreased significantly compared with the control group (P<0.01); there were no significant differences of the results of HR, CI and SI between two group, but the results of GEF, CFI and dPmax decreased in the test group (P<0.01), which indicated the decrease of contractive force of cardic. Unstable hemodynamic was common in brain-death patients, with the decrease of the pre-load, post-load and contractive force of cardic.