Biomedical Research

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Glycation of lens crystalline protein in the pathogenesis of various forms of cataract

The pathogenesis of cataract has been found to be influenced by number of factors including protein glycation. Cataract is the clouding or opacity that develops in the lens of eye. It forms when bounding or folding of protein changes and clump together; eventually these clumps cloud the lens and block the light. The aim of this study was to estimate the levels of glycated protein in blood and lens in patients with cataract. The levels of protein glycation both in serum and lens of controls and different type of cataract were studied. The levels of glycation of lens protein was significantly higher in both age related cataract (4.5±0.76 mg/100mg of protein) and diabetic cataract (5.22±1.07mg/100mg of protein) (p<0.001) when compared controls (2.42±0.3107mg/100mg of protein). Similarly the levels of glycated hemoglobin in diabetic cataract (8.33 ±1.04%) was significantly higher (p<0.001) when compared with controls (4.94±0.89 %). The levels of protein glycation were significantly higher in diabetic cataract (5.22±1.07mg/100mg of protein) (p<0.001) when compared with other types of cataract (nuclear cataract 4.5± 0.76mg/100mg of protein, cortical cataract 4.23±0.67mg/100mg of protein). These results show that the increase in glycation process may accelerates the development of cataract in diabetic patients.

Author(s): Ashok V. Katta, A.N. Suryakar, R.V. Katkam, Kayyum Shaikh, Santoshi R. Ghodake