Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 28, Issue 6

Fabrication and in vitro degradation behaviour of TCP/CS composite bioceramics

Ca3 (PO4)2 (TCP) bio-ceramic materials are known as the ideal bone repair materials because they possess good biocompatibility and biodegradability. In this study, β-TCP bio-ceramic materials were prepared by wet process through controlled process conditions. CaSiO3 and β-TCP bioceramics were ground and mixed to prepare the TCP/CaSiO3 (TCP/CS) bioceramic embryonic bodies. TCP/CS porous composites were obtained by sintering at 800°C. TCP/CS bioceramics possessed the best strength after sintering for 2 h; the sample strength was about 122 MPa, which is approximately consistent with the strength of human bone. The degradation behaviour of porous TCP/CS bioceramics were investigated by static soaking and dynamic dissolution experiments in physiological saline to control the degradation rate of TCP/CS. The degradability of TCP/CS samples reached 10% within 12 days in vitro, suggesting an excellent in vitro bioactivity and biodegradability of TCP/CS composite bioceramics. The TCP/CS composite bioceramics might become potential biomaterials as good mechanical strength, bioactive and biodegradable for bone tissue repair applications.

Author(s): Bin Xu, Hanyuan Zhang, Weijun Fang

Abstract Full Text PDF