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Exploration of serum levels of SOST and its clinical significance in elderly patients with type 2 diabetes mellitus complicated with osteoporosis

Objective: To observe the Serum Sclerostin (SOST) level of elderly patients with Type 2 Diabetes Mellitus (T2DM) complicated with Osteoporosis (OP), and to analyse the correlation between T2DM and OP and the clinical significance.

Methods: From January 2014 to December 2016, 210 elderly patients with T2DM were divided into two groups: T2DM complicated with OP group (group A) and T2DM group (group B), 105 cases in each group. 105 elderly healthy subjects were recruited as the control group (group C). The levels of serum FPG, 2hPG, FINS, HbAlc and SOST were measured in all subjects. HOMA-IR was calculated and the Bone Mineral Density (BMD) of the radius, femur and lumbar vertebrae of the three groups were measured and compared.

Results: The levels of FPG, 2hPG, FINS, HbAlc, HOMA-IR and SOST in groups A and B were significantly higher than those in group C (P<0.05). The FPG, 2 h PG and SOST levels in group A were significantly higher than those in group B (P<0.05). There was no significant difference in FINS, HbAlc and HOMA-IR between groups A and B (P>0.05). The BMDs of the radial, femur and lumbar vertebrae of group A were significantly lower than that of groups B and C (P<0.05), while there was no significant difference between groups B and C (P > 0.05). There was a linear positive correlation between SOST and FPG, 2 h PG, radial BMD, femur BMD and lumbar BMD (P<0.05).

Conclusion: The expression of serum SOST in elderly patients with T2DM complicated with OP is obviously increased, which may be related to the increase of blood glucose level. The interaction between them is of great significance in the occurrence and development of T2DM complicated with OP.

Author(s): Sun Xiaohong, Wang Difei