Biomedical Research

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Evaluation of vitamin D status and its correlation with glycated haemoglobin in type 2 diabetes mellitus

Background: The role of Vitamin D in various non-skeletal disorders including Diabetes Mellitus has been explored. The role of Vitamin D in peripheral utilization of glucose has been studied.

Aim: This study evaluates the correlation between Vitamin D status and Glycated Haemoglobin in Type 2 Diabetes Mellitus.

Subject and Methods: The present study was a retrospective case control study with 78 cases and 69 controls. Mann-Whitney Test was used to study difference in Vitamin D levels between cases and controls. Spearman correlation was used to study the correlation between Vitamin D levels and Glycated Haemoglobin in cases of Type 2 Diabetes Mellitus.

Results: The mean Vitamin D values in cases were 16.1 ng/ml and mean Vitamin D values in controls were 17.3 ng/ml. Though the mean values of Vitamin D in cases were lower than that of controls, the difference was not statistically significant (p=0.31). Vitamin D insufficiency was observed in both cases and controls. Spearman correlation showed there was no statistically significant correlation between Vitamin D levels and Glycated haemoglobin (p value 0.741) in cases of Type 2 Diabetes Mellitus.

Conclusion: Hypovitaminosis D and its correlation with Glycaemic control could not be established.

Author(s): Akshay Kumar SV, Sunil Kumar Nanda, Bharathy N, Ravichandran K, Asha Dinakaran, Lopamudra Ray