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Evaluation of the relationship between thromboembolic risk score (CHA2DS2-VASc) and inflammation and coagulation markers in patients with non-valvular atrial fibrillation in emergency department.

Objective: To evaluate the relationship between CHA2DS2-VASc score and inflammation and coagulation markers in patients admitted to Emergency Department (ED) with non-valvular Atrial Fibrillation (AF).

Methods and Results: Eighty-four patients with non-valvular AF were included in the study. CHA2DS2- VASc scores were calculated for these patients. In addition, plasma levels of BNP, hs-CRP, CRP, vWF and D-dimer were measured. The relationship between CHA2DS2-VASc score and these parameters were evaluated. Eleven (13%) patients were considered to be at low-risk due to CHA2DS2-VASc score being<2 and 73 (87%) patients were considered to be at high risk due to CHA2DS2-VASc score being ≥ 2. The mean age of patients was 68 ± 13 years and 50 (60%) of patients were male. Plasma BNP, hs-CRP, CRP, vWF and D-dimer levels were significantly higher in high-risk group. In addition, a significant positive correlation was found between CHA2DS2-VASc score and BNP (r=0.436, p<0.001), D-Dimer (r=0.356, p=0.003), hs-CRP (r=0.335, p=0.002), CRP (r=0,331, p=0.002), vWF (r=0.330, p=0.002) and patient age (r=0.573, p<0.001).

Conclusion: It was found that BNP, hs-CRP, CRP, vWF and D-dimer levels increase significantly and that there is a positive correlation between CHA2DS2-VASc and these markers in high-risk patients with CHA2DS2-VASc score ≥ 2.

Author(s): Fatih Nazmi Yaman, Birol Civelek, Bunyamin Yavuz, Mustafa Yilmaz, Metin Atescelik, Mustafa Sahan, Mehmet Cagri Goktekin