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Evaluation of serum hs-CRP concentrations in reproductive women with polycystic ovarian syndrome (PCOS)

Background: The polycystic ovary syndrome (PCOS) is an endocrine disorder in reproductive women, which interferes body structure, menstruation and fertility. Objectives: The present study was to evaluate the high sensitivity C- reactive protein (hs-CRP) levels in serum among women with PCOS and normal women in relation to insulin resistance (IR) and body mass index (BMI).

Materials and Methods: Twenty-five women with PCOS with age 18-35 years were taken as cases and twenty-five age-matched, normal and fertile women were considered as controls after obtaining written informed consent from all of them. Blood Samples were collected for estimation of fasting blood glucose, lipid profile, insulin and hs-CRP levels along with BMI estimation among all of them.

Results: Fasting Blood Glucose (FBG) and high-density lipoprotein (HDL) were not significant between PCOS and control groups. The PCOS group had a significant higher BMI (p=0.008), Insulin (p=0.002), total cholesterol (TC) (p=0.04), triglycerides (TG) (<0.001), LDL (p=0.004) and hs-CRP (p ≤ 0.001) levels compared with the control group. hs-CRP levels were negatively correlated with low density lipoprotein (LDL) (r=-0.552, p=0.004) and TC (r=-0.569, p=0.003) in women with PCOS.

Conclusion: The obese woman with PCOS has higher hs-CRP levels, which is an inflammatory marker, estimation of this may give information related to the cardiovascular system of the woman with PCOS and helps to prevent complications among them.

Author(s): Sampurna Koppalli, Vivekananda Reddy B, Vijayaraghavan R, Rajesh Paluru, Rangarao T, Sarma SSB