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Evaluation of resistance index (RI) values in patients with proteinuria: correlation of resistance index with biopsy findings

Background: Duplex Doppler sonography has been recognized as a noninvasive method to evaluate hemodynamic features of renal blood in renal and intrarenal arteries in patients with various renal diseases. The significance of duplex Doppler sonography in the evaluation of renal vascular resistance in glomerular diseases has not yet been clearly determined. The present study was performed to evaluate renal vascular resistance in patients with proteinuria by measuring intrarenal arterial resistance (RI) and the aim of this study is to evaluate the correlation between RI and pathologic results.

Methods: RI was measured 24 hours before renal biopsy in 99 patient’s admitted with proteinuria. Clinical and laboratory data were collected prospectively. We determined mean RI values in subtypes of decease according to the biopsy findings. Also correlation between RI with histopathological findings, age, gender, proteinuria level and serum creatinine level was evaluated.

Results: Among 99 patients with mean age of 45.92 ± 16.88 years, 61.61% were male. The mean RI was 0.65 ± 0.09. The most common biopsy based diagnosis was focal segmental glomerulosclerosis. The mean of RI in this group was 0.72 ± 0.1 which was statistically significantly higher than in other groups of patients. RI significantly correlated with age (P<0.01), serum creatinine (P<0.01) and proteinuria (P=0.02).

Conclusion: According to these findings, we recommended to evaluate RI in following patients with proteinuria, since the RI values could represent underlying disease injury.

Author(s): Shima Hedayatifar, Seyed Morteza Bagheri, Fatemeh Khajehasani