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Effects of nonsurgical periodontal therapy on serum inflammatory factor levels in patients with chronic kidney disease and periodontitis

Objective: To evaluate the effects of Nonsurgical Periodontal Therapy (NPT) on periodontal clinical parameters and Serum Inflammatory Factor (CRP, IL-6, TNF-α) levels of patients with Chronic Kidney Disease (CKD) and periodontitis.

Methods: Fifty-three patients were randomly divided into Groups A and B, and another 30 patients with periodontitis but without systemic diseases were included as Group C. Groups A and C were given NPT including ultrasonic scaling, subgingival scaling and root planning, as well as oral hygiene instruction. CKD of Groups A and B were further treated by routine methods, but Group B was only given oral hygiene instruction without any periodontitis treatment. Periodontal examination was performed and serum levels of CRP, IL-6 and TNF-α were detected before and 6 weeks after treatment.

Results: The attachment loss, probing depth and positive percentage of Bleeding On Probing (BOP%) of Groups A and C significantly decreased after treatment compared with those before treatment (p<0.05), and BOP% of Group B also significantly reduced (p<0.05). The serum hsCRP, IL-6 and TNF-α levels of Group A significantly dropped after treatment compared with those before treatment (p<0.05). The serum hsCRP and TNF-α levels significantly reduced (p<0.05), but that of IL-6 barely changed (p>0.05). Group C had significantly decreased serum levels of hsCRP and IL-6 (p<0.05), but that of TNF-α did not change significantly (p>0.05).

Conclusion: After patients with CKD and periodontitis received combined routine CKD treatment and NPT for 6 weeks, the serum hsCRP, IL-6 and TNF-α level all dropped.

Author(s): Nan Guo, Gengbing Lin