Biomedical Research

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Effects of garlic extract on adenosine deaminase, 5' nucleoditase, and xanthine oxidase enzymes in cancerous gastric tissues

Introduction: Present study aims to investigate possible effect of garlic extract on the activities of purine metabolizing enzymes, namely ADA, 5’Nucleoditase and Xanthine Oxidase in cancerous and noncancerous gastric tissue.

Methods: The study involved 14 cancerous and non-cancerous human gastric tissues, removed by surgical operations. The ADA, 5’ Nucleoditase, and Xanthine Oxidase (XO) activities were measured in all the tissues treated and not treated with the garlic extract.

Results: The enzyme activities were found to be significantly lower in benign and malign human gastric tissues treated with the garlic extract as compared with those of non-treated tissues.

Conclusion: Lowered purine-metabolizing enzyme activities observed in the garlic extract-treated gastric tissues suggested that garlic might have anti-carcinogenic and cancer-preventive effects on gastric tissue.

Author(s): Ozlem Dogan, Hikmet Can Cubukcu, Zahide Esra Durak, Hilmi Kocaoglu, Ilker Durak