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Effect of two common variants in PPAR-γ2 gene on susceptibility to obesity

Background/Aims: Association of genetic variants in the PPAR-γ2 gene with obesity and related phenotypes is widely scrutinized in recent years. However, there have been inconsistent findings in different populations. This study aimed to explore the association of PPAR-γ2 gene Pro12Ala and C1431T polymorphisms and their haplotypes with susceptibility to obesity and related traits in an Iranian population.

Methods: A total of 233 unrelated subjects, including 83 obese and 150 nonobese controls, were enrolled in this study. Anthropometric indices, fasting plasma glucose, and lipid profile were measured using standard protocols. Genotyping was done by TaqMan® SNP Genotyping Assay.

Results: Waist/hip ratio, systolic and diastolic blood pressure, triglyceride and fasting blood glucose showed a significant difference between groups. The genotype distributions were not significantly different between obese and non-obese subjects. However, in the obese group, the carriers of 12Ala risk allele had higher body weight (P=0.019), waist circumference (P=0.003), and waist/hip ratio (P=0.048) compared to the wild-type homozygotes. Haplotype analyses identified four common haplotypes with frequency greater than 1% but none of them was associated with the risk of obesity.

Conclusions: The present study suggests that Pro12Ala but not C1431T polymorphism of PPAR-γ2 gene is correlated with predisposition to obesity related markers.

Author(s): Hassan Mehrad-Majd, Majid Ghayour-Mobarhan, Mohammad-Reza Zali