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Effect of epidermal growth factor receptor gene mutation on bevacizumab combined with erlotinib in the treatment of non-small cell lung cancer

Objective: To investigate the effect of epidermal growth factor receptor gene (EGFR) mutation on bevacizumab combined with erlotinib in the treatment of non-small cell lung cancer.

Methods: Fifty-nine patients with non-small cell lung cancer (NSCLC) underwent radical resection of lung cancer were divided into two groups: mutant group (n=36) and non-mutant group (n=59). All the patients were treated with bevacizumab combined with erlotinib. Recent clinical efficacy, side effects and survival conditions were compared between the two groups of patients.

Results: The total effective rate was 77.78% in the mutant group and 44.07% in the non-mutant group. The difference was statistically significant (P<0.05). The incidence of rash, bleeding and diarrhea in the mutant group was significantly lower than that in the non-mutant group (P<0.05). The overall survival of the patients in the mutant group was significantly better than that in the non-mutant group (P<0.05).

Conclusions: Compared with EGFR non-mutation patients, bevacizumab combined with erlotinib is more effective in the treatment of patients with non-small cell lung cancer mutations with EGFR gene mutations, with better patient tolerance, and can extend the overall survival time of patients.

Author(s): Gao Yuan