The purpose of this work was to observe the effects of early application of digitalis on heart function, hemodynamics, and laboratory indexes in patients with Acute Myocardial Infarction (AMI) complicated with heart failure after Percutaneous Coronary Intervention (PCI). We recruited 54 patients with AMI complicated with heart failure after undergoing emergency PCI and randomly divided them into control and experimental groups. The experimental group was treated by digitalis preparation after reperfusion while the control group received saline injection. Left Ventricular End-Diastolic Diameter (LVEDD) increased in both groups, but there were no significant differences between the two groups. Left Ventricular Ejection Fraction (LVEF) was higher in the experimental group than in the control group. Heart Rate (HR), in the experimental group was lower than those in the control group after medication. Stroke Volume (SV) was higher in the experimental group than that in the control group 1 h after medication. The changes in Central Venous Pressure (CVP), Pulmonary Artery Systolic Pressure (PASP), and Cardiac Index (CI) were not significantly different between the two groups. The values of Brain Natriuretic Peptide (BNP), Creatine Kinase isoenzyme MB (CK-MB), and Troponin I (TnI) improved significantly in both groups after surgery. The incidence of ventricular arrhythmia and mortality rate 30 d post-surgery were similar in the two groups. Overall, the heart function and hemodynamic indexes of patients with AMI complicated with heart failure after PCI can be significantly ameliorated after intervention with digitalis drugs without increasing the adverse events.