Research Article - Biomedical Research (2017) Volume 28, Issue 15

Diffuse large B cell lymphoma-related prognostic factors, Ki-67 and Bcl-6 expression levels

Objective: This study aims to investigate the diffuse large B cell lymphoma-related prognostic factors, Bcl-6 and Ki-67 expression levels.

Methods: 67 cases of patients with diffuse large B cell lymphoma in our hospital were collected from Feb 2014 to Mar 2015. The Bcl-6 and Ki-67 expression levels in patients with diffuse large B cell lymphoma were detected using the immunohistochemical method. The related characteristics and prognosis were analyzed.

Results: Statistical analysis shows that the Bcl-6 protein expression levels are not related to sex or age; Ki-67 is not related to sex but related to age. Bcl-6 is not related to lactate dehydrogenase or primary site but is related to Ann Arbor stage. Ki-67 is related to lactate dehydrogenase and Ann Arbor stage.

Conclusion: The microvessel density dose, Bcl-6-positive rate and Ki-67 labelling index of diffuse large B cell lymphoma are important indexes to evaluate the prognosis of patients with diffuse large B cell lymphoma.

Author(s): Rong Xie, Jing Tang, Sheng Hu, Hui Jiang

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