Biomedical Research

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Diagnostic value of standardized ultrasonography during early pregnancy in fetal malformation screening

Objective: To investigate the diagnostic value of standardized ultrasonography during early pregnancy in fetal malformation screening.

Methods: From July 2015 to July 2017, 2534 pregnant women enrolled in our hospital to receive fetal malformation screening during early pregnancy were selected as the objects. All pregnant were given standardized ultrasonography at 11~13+6 w of gestation to acquire the information of baby’s Crown Rump Length (CRL), Nuchal Translucency (NT), fetal abnormalities and chromosomal abnormalities. The effect of ultrasound was analysed by comparing its result with the result of induction delivery.

Results: In these 2534 pregnant women, 25 cases of fetal malformation were detected by standardized ultrasonography during early pregnancy with the diagnostic accuracy rate highly reaching 96%. CRL and NT of the parturient women at 13-13+6 w of gestation were significantly higher than those of the pregnant at 12-13+6 w and 11-12+6 w of gestation; The CRL and NT of the parturient women at 12-13+6 w of gestation were obviously higher than those of the women at 11-12+6 w of gestation and the difference had statistical significance (P<0.05). The ultrasound examination result showed that in these 2534 pregnant women 33 cases were fetal NT thickening. NT thickening of 3.0-4.9 mm was found in 20 cases in which there were 2 cases of induction delivery and 18 cases of normal postpartum. NT thickening of 5.0-6.0 mm was seen in 7 cases in which there were 4 cases of chromosome abnormalities, 4 cases of induction delivery and 3 cases of normal postpartum. NT thickening beyond 6.0 mm was observed in 6 cases in which there were 6 cases of induction delivery with no normal postpartum. The fetal normal rate after delivery of the women with NT thickening beyond 6.0 mm was significantly lower than that of those with NT thickening of 5.0-6.0 mm and NT thickening of 3.0-4.9 mm of statistical significance (P<0.05).

Conclusion: Standardized ultrasonography in early pregnancy has good effects in fetal malformation screening.

Author(s): Xia Yu, Hongjie Wang, Xin Zheng, Haiying Zhu, Juanjuan Pang