Biomedical Research

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Determination of frequencies by the number of active substances used in a hypertensive population

Aim: The present study aimed to evaluate the distribution of antihypertensive drugs prescribed to patients with hypertension who were granted drug exemption report in the period of June 2016-2017 with respect to their classes and active substances and to investigate which class of drugs and active substances are used more frequently.

Material and Methods: Drug exemption reports from the hospital’s digital database granted between 2015 and 2016 were evaluated. Patients with a diagnosis code of hypertension were included, and approximately 65,000 records were obtained.

Results: Study records showed that there were 36 active substances, with 28 active substances used in combination with these active substances. Therefore, a total of 64 different active substances are present. It was demonstrated that participants in the study concomitantly used up to seven active substances.

Discussion: The main objective in the treatment of hypertension is to prevent the occurrence of cardiovascular events, reduce the risk, and prevent organ damage. Lifestyle changes (salt-free diet, achieving ideal weight and exercise) are the first steps of treatment and should be offered in all treatment steps.

Author(s): Dilek Oztas, Huseyin Balcioglu, Yasemin Saglan, Yunus Emre Sari