Gynecology and Reproductive Endocrinology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-1235-425476

Research Article - Gynecology and Reproductive Endocrinology (2017) Volume 1, Issue 1

Day 4 embryos should not be underestimated in IVF.

Background: 2-3 and Day 5 fresh and frozen-thawed embryos are most frequently used in ART, while the results of Day 4 embryo transfers are seldom reported in the literature. However, the use of Day 4 embryos in clinical practice increases flexibility when choosing the embryo transfer day, and enables avoiding embryo transfers on weekends. Methods and findings: We conducted a retrospective cohort study (1.1.2009-31.12.2014) comparing the clinical outcomes of fresh Day 3 (n=1371), Day 4 (n=360) and Day 5 (n=326) and vitrified-warmed Day 3 (n=635), Day 4 (n=175) and Day 5 (n=654) embryos. The live birth rates of fresh Day 3, Day 4 and Day 5 embryo transfers were 26.5%, 31.4% and 24.5%, respectively (p=0.026). The miscarriage rates were 16.6%, 11.7% and 23.0%, respectively (p=0.017). The live birth rates of Day 3, Day 4 and Day 5 vitrified-warmed embryo transfers were 22.0%, 30.9% and 22.6%, respectively (p=0.024). The miscarriage rates were 21.6%, 15.9% and 27.8%, respectively (p=0.049). Conclusions: The results of the present study show that Day 4 embryo transfers produce good clinical outcomes and can be considered for wider utilization at IVF clinics.

Author(s): Noora Kaartinen, Kirsi Kananen, Candido Tomás, Helena Tinkanen

Abstract Full Text PDF