Biomedical Research

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Curative effects and safeties of excision and interventional therapy as treatments for early intrahepatic recurrence and metastasis after primary hepatocellular carcinoma operation

Objective: This study aims to compare the effects of excision with those of interventional therapy on early postoperative intrahepatic recurrence and metastasis of primary hepatocellular carcinoma.

Method: A total of 80 patients with early postoperative intrahepatic recurrence and metastasis of primary hepatocellular carcinoma who were treated in our hospital from January 2012 to 2013 were equally divided into the operation group (n=40) and the intervention group (n=40) according to random number table method. The patients in the operation group were subjected to reoperation excision, whereas those in the intervention group were subjected to embolotherapy. The curative effects of the operation group were then compared with those of the intervention group.

Results: The one-, two-, and three-year survival rates of the patients in the observation group were significantly higher than those in the control group (P<0.05). No significant difference was observed between the White Blood Cell (WBC) and Alpha-Fetoprotein (AFP) levels of the two groups before treatment (P>0.05). The patients in the observation group had significantly higher WBC levels than the control group (P<0.05) after their respective treatments. Meanwhile, the AFP levels had opposite results (P<0.05). The liver fiber indexes in the observation group were significantly lower than those in the control group (P<0.05). Furthermore, no significant difference was observed between the occurrence rates of adverse reactions of the two groups (P>0.05).

Conclusion: Excision can improve the WBC and AFP levels of patients with early postoperative intrahepatic recurrence and metastasis of primary hepatocellular carcinoma. This method can also decrease the extent of fibrosis effectively and increase survival rate.

Author(s): Yu-Jun Shi, Wei Hu, Lu-Jun Wang, Jia-Fu Liu