Biomedical Research

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Correlation between H. pylori infections and expressions of P53, Bax and FHIT in patients with gastric cancer

Objective: It was designed to investigate the relationship between H. pylori infections in the patients with gastric cancer and P53, Bax, FHIT proteins expression.

Method: 180 patients with gastric cancer admitted in our hospital from January 2015 to December 2015 were selected to detect H. pylori infections and was divided into positive group and negative group according to the infection results. The expression of P53, Bax and FHIT proteins in cancer tissue of all patients was detected.

Result: in 180 patients with gastric cancer, there were 120 positives infected with H. pylori, 60 negatives and the positive rate was 66.67%; for patients in positive group, the positive rate of P53 protein expression was 58.3%, while for patients in negative group, it was only 15.0%, and there was statistical difference between group data (P<0.05); the positive rate of Bax protein expression for patients in positive group was 67.5%, 21.67% for those in negative group, and there was statistical difference between group data (P<0.05); the positive rate of FHIT protein expression for patients in positive group was 52.5%, 25.0% for those in negative group, and there was statistical difference between group data (P<0.05).

Conclusion: It has been concluded that P53, Bax, FHIT gene in H. pylori infections for patients with gastric cancer were all in high expression and the gastric cancer might be resulted from the influence of H. pylori on P53, Bax, FHIT.

Author(s): Li-hua Zhou, Shun-jun Li, Ren-yi Zhang, Yun-chao Yang, Shuang Zhang