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Correlation between brain magnetic resonance imaging and blood inflammatory markers for patients with vascular cognitive impairment

Objective: The aim was to research the correlation between brain magnetic resonance imaging and blood inflammatory markers for patients with varying degrees of vascular cognitive impairment.

Methods: Total 90 subjects were divided into vascular cognitive impairment with no dementia, vascular dementia and control group. The Chinese version of the Montreal Cognitive Assessment, Clinical Dementia Rating, activities of daily living scale and Hachinski Ischemic Scale were used for tests; the magnetic resonance imaging consisted of routine scanning sequences, susceptibility weighted imaging and diffusion tensor imaging; cardiopulmonary resuscitation, interleukin-6 and tumor necrosis factor-α were detected by enzyme-linked immunosorbent assay.

Results: Microbleeds mainly appeared under the cortex of frontal lobe and temporal lobe and in the basal ganglia, centrum semiovale, corona radiate and thalamus; the number of the microbleeding parts were larger than those of the vascular cognitive impairment with no dementia. The fractional anisotropy values in the parts under the cortex of frontal lobe and temporal lobe and in the basal ganglia, centrum semiovale, corona radiate and thalamus were lower than those of the vascular cognitive impairment with no dementia and the apparent diffusion coefficient values increased. Cardiopulmonary resuscitation, interleukin-6 and tumor necrosis factor-αlevel of the vascular dementia were higher than those of the vascular cognitive impairment with no dementia.

Conclusion: It was valuable for early diagnosis of vascular cognitive impairment and assessment of its severity to detect microbleeds by the susceptibility weighted imaging on magnetic resonance, examine Leukoaraiosis by the diffusion tensor imaging and the levels of serum inflammatory markers.

Author(s): Wuqing Zhang, Yaming Lin, Jianming Lai, Yong Quan, Yifeng Du, Xiaohong Li