Research Article - Biomedical Research (2018) Volume 29, Issue 4

Composition of pathogenic bacteria of chronic obstructive pulmonary disease patients and drug resistance of gram-negative bacilli for various antibiotics

Objective: In order to analyze the composition and characteristics of pathogens resistance, provide reference for rational use of antibiotics, clinical bacteria isolated from COPD patients in our hospital was investigated.

Methods: The 710 patients with chronic obstructive pulmonary disease were collected from August 2010 to February 2014. All patients required to multiple gargle with water or hydrogen peroxide before collecting specimens, ensuring a sterile culture spit sputum specimen box. Susceptibility was determined by the United States Committee for Clinical Laboratory Standards (NCCLS) developed by KB.

Results: Gram-negative bacteria as the main species which 813 species were isolated from 710 cases of patients with chronic obstructive pulmonary disease. Pseudomonas aeruginosa based. Gram-positive bacilli was in second place, Staphylococcus aureus, fungi ranks No. 3, Gram-negative bacilli species number and composition were significantly higher than that of Gram-positive bacteria and fungi, and the difference was statistically significant (p<0.05). Pseudomonas aeruginosa and Acinetobacter baumannii resistant to cefazolin higher rate, the difference was statistically significant (p<0.05).

Conclusion: Gram-negative bacteria are the main pathogens, and resistance was so strong. So we need to constantly monitor the bacteria resistance, and to guide rationally clinical medicine.

Author(s): Lin Chen, Zheng-Liang Xie, Yang Yang

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