We aim to analyse the time consumption, image quality and efficacies of dual-source Computed Tomography (CT) Dual-Energy Angiography (DE-CTA) in diagnosing vascular stenosis. The medical records of 35 patients with clinically suspected caudomedial vascular diseases were performed DE-CTA. The residual bone images obtained in DE-CTA and conventional 3D software were compared, as well as the sensitivity and specificity of these two imaging methods in diagnosing the segment with vascular stenosis ≥ 50%. The results showed that the overall effects of Automatic Bone Remove (ABR) were better than Automatic Bone Subtraction (ABS) (P<0.05); the post-processing time consumption of ABS and plaque subtracted after Additional Manual Bone Remove (ABPS) (7.62 ± 2.13 min) was less than that in automatic bone remove after Additional Manual Bone Remove (ABR-M) (11.4 ± 2.5 min), and the difference was statistically significant (P<0.05). The sensitivity and specificity in ABPS and ABR-B towards the segment with stenosis ≥ 50% were: 95.67%, 96.26% and 93.78%, 98.23%, respectively. In conclusion, DE-CTA had better image quality after bone subtraction, could much more accurately diagnose the vascular stenosis, the post-processing time consumption was less than the conventional 3D method, and not affected by human factors.