Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2019) Volume 30, Issue 5

Comparing Ficus vogelii leaf extract and omeprazole as therapy and prophylaxis for aspirin-induced gastric ulcer in wistar rat.

Background: A proper attention is required to prevent the gastric mucosa from injurious effect of aspirin. Objective: We aim to examine the phytochemicals in aqueous extract of Ficus vogelii leaf (F.V.E), and compare their actions on aspirin-induced gastric ulcer with that of Omeprazole. Materials and Methods: Thirty wistar rats (about 8 wks old and weight, 120g each) were divided into 6 groups of five rats each. With the aid of oro-gastric cannula, the groups were administered a daily dose of Omeprazole and F.V.E as follows: group 1 (negative control)-2 ml of distilled water; group 2– Omeprazole 20 mg/kg body weight (bwt) for 10 days, followed by aspirin 500 mg/kg bwt for 3 days; group 3-aspirin 500 mg/kg bwt for 3days, followed by F.V.E 600 mg/kg bwt for 10 days; group 4-aspirin 500 mg/kg bwt for 3 days, followed by Omeprazole 20 mg/kg bwt for 10 days; group 5-F.V.E 600 mg/kg bwt for 10 days, followed by aspirin 500 mg/kg bwt for 3 days; group 6 (positive control)-aspirin 500 mg/kg bwt for 3 days. The rats were sacrificed and the stomach tissues were processed, stained with H & E and PAS, and biochemically analyzed for NP-SH group concentration. Results: F.V.E has high concentrations of saponins and flavonoids. Rats in group 1, 4 and 5 showed normal gastric mucosa. Group 2 and 6 showed gastric ulceration with significant increase in parietal cell count (p<0.01), and reduction in surface cell diameter and count. Group 3 showed evidence of regenerated mucosa. All groups except positive control had normal NP-SH group concentration. Conclusion: The study proved that F.V.E could be used as both therapy and prophylaxis for aspirininduced gastric ulcer in wistar rat while omeprazole adequately served as a therapy for the ulcer.

Author(s): Ezemagu UK, Akunna GG, Egwu OA, Uzomba GC, Nwite KN

Abstract Full Text PDF