Biomedical Research

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Comparative study on the effect of breast conserving surgery and modified radical operation in patients with early stage breast cancer

Objective: To investigate the effect of breast conserving surgery and modified radical operation modified radical operation for early stage breast cancer patients.

Methods: A retrospective analysis of 100 cases of early breast cancer patients in our hospital from January 2010 to November 2011 were divided into conserving group (n=50, using breast conserving surgery) and radical group (n=50, using modified radical operation) according to the different surgical methods. Operation time, intraoperative bleeding, hospitalization time and the incidence of adverse reactions were compared between groups. According to follow-up data of two groups, postoperative local recurrence rate, distant metastasis rate and 3 y and 5 y survival rate were compared. Short form of health survey was used to describe the quality of life after operation.

Results: Operation time, blood loss, length of stay and incidence of adverse reactions were significantly lower in conserving than in radical group (P<0.05). Postoperative follow-up showed that there was no significant difference between the two groups in postoperative local recurrence rate, distant metastasis rate and postoperative 3 y and 5 y survival rate (P>0.05). The scores of life quality in conserving group were significantly higher than those in radical group (P<0.05).

Conclusion: For patients with early breast cancer, breast conserving surgery has similar effect to modified radical operation with reduced operation time, reduced bleeding, shortened hospitalization time and improved survival time of patients.

Author(s): Jian-xiu Cui