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Comparative of early parenteral nutrition and late parenteral nutrition in preterm neonates.

Objective: To evaluate the differences and influences of early and late Parenteral Nutrition (PN) on preterm neonates.

Methods: Retrospective study, which includes preterm neonates who were born and admitted to Neonatal Intensive Care Units (NICU), weighing under 2000 g and having received PN for more than 7 days. According to the timing of protein provision, divided into two groups-Early Parenteral Nutrition (EPN) and late parenteral nutrition (LPN). EPN is defined with a protein provision within 24 h of birth while LPN with a protein provision after 24 h of birth. The facts to examined include the day of weight gain (times to regain over birth weight), total days of PN, weight gain per day in grams (g), weights at discharge and days of hospitalization.

Results: Among a 25 preterm neonates, 10 neonates received EPN while 15 received LPN. No statistical significance is found between the basic data of EPN and LPN. After the multiple regression analysis and correction of basic data’s between EPN and LPN, this study finds that the day of weight gain of EPN is earlier than that of LPN by about 0.41 day, weight gain per day in grams (g) and the weight at discharge of EPN are more than those of LPN by about 0.25 g and 0.27 g, respectively, and the total days of PN and the days of hospitalization in the NICU of EPN are more than those of LPN by about 0.15 day and 0.11 day respectively, however, none of the above is statistically significant.

Conclusion: The results of this study show that early PN may provide the benefits to preterm neonates. No evidence is noted in blood urea blood urea nitrogen and creatinine level.

Author(s): Tzu-Rong Peng, Fang-Pei Tsai, Ta-Wei Wu